Human Research Coordination

The purpose of this study is multifaceted as we seek to understand how 1. The timing of daily rest, activity, and meal consumption, 2. The regularity of day-to-day rest, activity, and meal consumption, and 3. The intensity of daily activity relative to rest relate to various subclinical markers of CVD and future CVD risk in a heterogeneous group of young and early middle-age adults.

You are being asked to participate because…
• You are a healthy adult between the ages of 18-45
o Female participants must be premenopausal

You may not be able to participate if you:
• Are unwilling or unable to give consent
• Do not have regular access to a smart phone
• Participate in regular extended fasting in the morning (e.g., do not eat prior to 12pm, consume 1 meal per day, engage in ≥16 hour periods without caloric consumption) or full day fasting
• Are engaging in a weight-loss regimen, including a calorie-restricted diet, during study enrollment
• Unstable body weight (>4.5 kg/~10 lbs. change) over last 3-months
• Have been diagnosed with any chronic disease (a history of high blood pressure, heart disease, diabetes, cancer, kidney disease)
• Have had a positive COVID-19 test within the past 60 days
• Have received a COVID-19 vaccination within the past 14 days
• Have been diagnosed with a sleep disorder (e.g., insomnia, restless leg syndrome, sleep apnea) or are high risk for a sleep disorder as determined by the ISI (score >14) or STOP-bang (score ≥3) questionnaires
• Resting blood pressure >140/90 mmHg
• Body mass index 35 kg/m2
• Currently take any supplements or medications for sleep
• Currently take medication that may alter vascular function
• Currently working night-shift work
• Are diagnosed with depression or score ≥16 on the Center for Epidemiologic Studies Depression Scale
• Are currently pregnant, breast feeding, perimenopausal or post-menopausal (females only)
• Currently use tobacco (≥1 cigarette in the last month)
• Meet criteria for suspected alcohol use disorder (AUDIT score ≥15)